How Long does Hydroxychloroquine Stay in your System?

Hydroxychloroquine, a medication used to treat various conditions like malaria, systemic lupus erythematosus, and rheumatoid arthritis, has a long half-life of elimination, ranging from 40 to 50 days. It takes about 6 months for hydroxychloroquine to achieve full elimination from the body. The drug reaches 95% of its steady-state concentration after approximately 6 months of therapy, emphasizing the importance of a 6-month trial to assess its full clinical effects. The variability in pharmacokinetics among individuals can impact the drug's efficacy, with lower blood concentrations associated with treatment failure and higher concentrations linked to improved outcomes in autoimmune diseases like cutaneous lupus erythematosus.

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